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目的观察小剂量阿司匹林联合泼尼松治疗复发性流产(RSA)的临床效果。方法将RSA患者70例随机分为观察组和对照组各35例,观察组采用小剂量阿司匹林联合泼尼松,对照组采用常规保胎治疗,观察2组患者治疗成功率和治疗前后绒毛膜促性腺激素(HCG)、孕酮(P)、雌二醇(E2)水平。结果观察组治疗成功率为94.29%明显高于对照组的77.14%,差异有统计学意义(P<0.05);2组患者治疗前HCG、P、E2水平比较差异均无统计学意义(P>0.05),治疗后2组HCG、P、E2水平均升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。结论小剂量阿司匹林联合泼尼松治疗RSA效果显著,治疗成功率高,能显著改善患者激素水平,值得临床推广使用。
Objective To observe the clinical effect of low-dose aspirin combined with prednisone in the treatment of recurrent spontaneous abortion (RSA). Methods Seventy patients with RSA were randomly divided into observation group (35 cases) and control group (35 cases). The observation group was treated with low-dose aspirin combined with prednisone, while the control group was treated with conventional tocolytic therapy. The success rate of treatment and the improvement of chorionic Gonadotropin (HCG), progesterone (P), estradiol (E2) levels. Results The success rate of treatment in observation group was 94.29%, which was significantly higher than that in control group (77.14%) (P <0.05). There was no significant difference in HCG, P and E2 levels between two groups before treatment (P> 0.05). After treatment, the levels of HCG, P and E2 increased in both groups, and the difference between the two groups was statistically significant (P <0.05). Conclusion Low-dose aspirin combined with prednisone treatment of RSA significant effect, high success rate, can significantly improve the patient’s hormone levels, worthy of clinical promotion and use.