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[目的]探讨妊娠24～28周的健康孕妇维生素D水平与血脂的相关性.[方法]选取2012年5月至2013年8月期间秦皇岛市第一医院产科门诊就诊的91例妊娠24～28周的健康孕妇为观察组,同时选取同时期于本院体检中心就诊的63例健康非妊娠女性为对照组.收集所有受试者姓名、年龄、身高、体重、孕周,测定25羟维生素D[25(OH)D]浓度、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等临床资料,比较两组研究对象一般资料及血清指标比较,并对血清25(OH)D水平与血脂相关性进行分析.[结果]观察组与对照组的年龄分布比较,差异无统计学意义(P＞0.05);观察组BMI明显高于对照组(P ＜0.001).观察组血清25(OH)D水平显著低于对照组,差异具有统计学意义(P＜0.001);观察组血清TG、TC、HDL-C、LDL-C水平显著高于对照组,差异均具有统计学意义(均P＜0.05).观察组25(OH)D水平与TC(r=-0.397,P=0.039＜0.05)、LDL-C(r=-0.301,P=0.041＜0.05)呈显著负相关,与年龄、BMI、TG、HDL-C均无显著相关性(均P ＞0.05).[结论]孕中期健康孕妇25(OH)D水平与血脂显著相关.“,”[Objective]To evaluate the relationship between serum vitamin D level and blood cholesterol in healthy pregnant women at 24～28 weeks of gestation.[Methods]Ninety-one healthy pregnant women with 24～28 weeks gestation were enrolled as the experimental group,and sixty-three non-gestational healthy women were recruited as the control group.All cases were from our hospital from May 2012 to August 2013.General information (name,age,height,weight,gestational weeks) and clinical data (triglyceride/TG,low density lipoprotein cholesterol/LDL-C,high-density lipoprotein cholesterol/HDL-C,total cholesterol/TC and serum vitamin D [25 (OH) D] levels were collected,and the relation between blood cholesterol and serum vitamin D was analyzed.[Results]There was no significant difference between the experimental group and the control group (P ＞0.05).The BMI of the experimental group was significantly higher than that of the control group (P ＜0.001).The level of serum 25 (OH) D in the experimental group was significantly lower than that in the control group (P ＜0.001),while levels of serum TG,TC,HDL-C and LDL-C were significantly higher than those in the control group (P ＜0.05).The level of 25 (OH) D in the experimental group was significantly negatively correlated with TC (r =-0.397,P =0.039) and LDLC (r =-0.301,P =0.041).However,it did not show significant correlation with age,BMI,TG,and HDL-C (P ＞0.05).[Conclusion]Serum vitamin D level is significantly related to the blood cholesterol in women at middle gestational period.