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目的:调查广州市妇女儿童医疗中心儿童院区住院患儿使用利奈唑胺的情况,为临床合理用药提供参考。方法:抽取2010年至2011年该院住院患儿使用抗生素医嘱共822 279条,回顾性分析利奈唑胺的使用情况及不良反应等。结果:使用利奈唑胺医嘱1 930条(0.23%);用于治疗化脓性脑膜炎占治疗病种的53.94%,不符合适应证;单用医嘱与联用医嘱分别占利奈唑胺医嘱的70.00%、30.00%;无预防用药;未发生严重不良反应。结论:该院儿科利奈唑胺使用存在一些不合理用药情况,主要为用于治疗化脓性脑膜炎不符合适应证要求,仍需开展更多的临床研究以促进其合理使用。
Objective: To investigate the use of linezolid in children hospitalized in Guangzhou Women and Children’s Medical Center to provide reference for rational clinical use. Methods: A total of 822 279 antibiotic prescriptions were collected from children hospitalized in our hospital from 2010 to 2011. The use of linezolid and adverse reactions were retrospectively analyzed. Results: 1 930 lines (0.23%) of linezolid were used, 53.94% of them were used for the treatment of purulent meningitis, which did not meet the indications. The rates of single-use prescription and combined medical advice accounted for 70.00 %, 30.00%; no prophylaxis; no serious adverse reactions. CONCLUSIONS: There is some irrational use of pediatric linezolid in this hospital, mainly for the treatment of purulent meningitis, which does not meet the indication requirements. More clinical studies are still needed to promote its rational use.