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根据毒理学试验数据讨论四氯乙烯急性吸入毒性的剂量-反应关系。首先总结了有关四氯乙烯急性暴露的毒理学试验数据,并利用分类回归的方法,得出了小鼠、大鼠与人类暴露于四氯乙烯时,暴露时间、暴露浓度与健康后果之间的关系,同时分析了不同受试动物的种间差异。结果表明,健康效应的发生概率随暴露浓度和时间的增大而增大,而当暴露浓度达到某一值的时候,健康后果的发生概率不再随浓度变化而变化,将这一浓度视为饱和浓度;不利效应(AE)对应的饱和浓度要低于剧烈效应(SE),且暴露时间越长,饱和浓度则越低,同时饱和浓度随受试动物的不同而变化,人类的饱和浓度最低,大鼠的则最高。
The dose-response relationship of acute inhalation toxicity of tetrachlorethylene was discussed based on toxicological test data. First of all, toxicological test data on acute exposure to tetrachlorethylene were summarized and the method of classification regression was used to determine the exposure time, exposure concentration and health consequences between mice, rats and humans when exposed to PCE Relationship, at the same time analyzed the different species tested interspecific differences. The results showed that the probability of occurrence of health effects increased with the increase of exposure concentration and time, and when the exposure concentration reached a certain value, the probability of occurrence of health consequences no longer changed with the change of concentration, which was regarded as Saturation concentration; Adverse effect (AE) corresponding to the saturation concentration is lower than the dramatic effect (SE), and the longer the exposure time, the lower the saturation concentration, while the saturation concentration varies with the animals tested, the lowest saturation in humans , The highest in rats.