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自身免疫性肝病(AID)是指一组以肝脏的病理损害以及肝功能的异常为主要表现的非传染性肝病,其发病机制经研究发现可能与自身免疫机制有关,根据其临床表现、影像学、免疫学检查等特点,可以将AID分为自身免疫性肝炎(AIH),原发性胆汁性肝硬化(PBC)和原发性硬化性胆管炎(PSC),以及这三种疾病中任意两者的重叠综合征,其中以AIH-PBC重叠综合征多见。以上所述的几种AID类型均可进展为肝硬化,严重甚至导致肝癌。且随着时代发展,AID的发病率逐年升高,因此作为晚期慢性肝功能衰竭主要病因之一的AID的诊断及治疗研究逐渐成为目前肝病领域研究的热点。本文正是通过对自身免疫病的临床生化特征、免疫学等方面的特点对该病的诊断及治疗进行了解及分析。
Autoimmune liver disease (AID) refers to a group of pathological liver damage and abnormal liver function as the main manifestation of non-communicable liver disease, the pathogenesis of the study may be related to autoimmune mechanisms, according to their clinical manifestations, imaging , Immunological tests and other characteristics, can be divided into AID autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), as well as any two of these three diseases Overlap syndrome, including AIH-PBC overlap syndrome more common. Several types of AID described above can progress to cirrhosis, severe and even lead to liver cancer. And with the development of the times, the incidence of AID is increasing year by year. Therefore, the diagnosis and treatment of AID as one of the major causes of advanced chronic liver failure gradually become the hotspot in the field of liver disease. This article is through the clinical biochemical characteristics of autoimmune diseases, immunology and other aspects of the diagnosis and treatment of the disease to understand and analyze.