以廉价易得的2,4,6-三羟基苯乙酮为原料,经Aldol缩合和AFO反应,合成了一系列天然橙酮类化合物,总收率29%左右。为天然产物橙酮的全合成提供了一种简洁的合成方法。各中间体及产物结构经MS、IR、~1H NMR、~(13)C NMR、2D NMR等方法确证。 A series of natural orange ketone compounds were synthesized by using Aldol condensation and AFO reaction at low cost and afford 2,4,6-trihydroxyacetophenone. The total yield was about 29%. For the natural synthesis of total synthesis of orange ketone provides a concise synthesis. The intermediates and their structures were confirmed by MS, IR, ~ 1H NMR, ~ (13) C NMR, 2D NMR and other methods.