论文部分内容阅读
将实验孕鼠随机分为5组,供实验的4个组于第7～18d 分别每天口服1.00、0.10、0.05及0.01mg/kg 敌枯双;对照组口服0.5%羧甲基纤维素钠。于孕20d 处死,取骨髓按常规细胞培养、镜检,发现各实验组的细胞畸变率均比对照组高,有高度显著性或显著性。说明其阈剂量在0.01mg/kg 以下,为一强的诱变剂。畸变的类型主要有断片、断裂、微粒、粉碎及多倍体等。
The experimental pregnant rats were randomly divided into 5 groups, and the experimental groups were orally administered 1.00, 0.10, 0.05 and 0.01 mg/kg of origandipine on the 7th to 18th day, respectively; the control group was orally administered with 0.5% sodium carboxymethylcellulose. After being sacrificed at the 20th day of pregnancy, bone marrow was routinely cultured and examined by microscopy. It was found that the cell aberration rate of each experimental group was higher than that of the control group and was highly significant or significant. It shows that the threshold dose is below 0.01mg/kg, which is a strong mutagen. The types of distortion mainly include fragments, fractures, particles, crushing, and polyploidy.