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目的:制备利巴韦林口腔崩解片,并评价其质量。方法:直接粉末压片法制备口腔崩解片。以片剂外观、口腔崩解时限、口感为指标,采用正交试验设计优化处方,并对其溶出度进行检测。结果:所得片剂完整光洁,口感良好,能在30 s内崩解完全,2 min内溶出百分率>90%。结论:利巴韦林口腔崩解片处方设计合理,制备工艺可行,产品质量可控。
OBJECTIVE: To prepare ribavirin orally disintegrating tablets and evaluate their quality. Methods: Orally disintegrating tablets were prepared by direct powder tabletting. The tablet appearance, oral disintegration time and mouthfeel were used as indexes, orthogonal design was used to optimize the prescription and its dissolution was tested. Results: The obtained tablet was smooth and clean with good mouthfeel. It could disintegrate completely within 30 seconds, and its dissolution percentage was higher than 90% within 2 minutes. Conclusion: The ribavirin orally disintegrating tablets prescription design is reasonable, the preparation process is feasible, product quality controllable.