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目的:探讨老年性黄斑变性新生血管(CNV)的中西医结合疗法及其临床效果。方法:选择2014年1月至2016年1月本院收治的78例老年性黄斑变性CNV患者,随机分为对照组和观察组,各39例。对照组常规采用玻璃体腔内注射雷珠单抗(Lucentis)治疗,观察组在对照组基础上增加补肝益肾祛瘀汤治疗,观察两组患者的临床疗效、CNV渗漏、黄斑区视网膜和CNV复合体厚度及术后6个月复发情况。结果:观察组近期总有效率为94.87%,显著高于对照组(74.36%),观察组CNV渗漏完全消失(23.08%)、大部分消失(25.64%)和部分消失(46.15%)概率显著高于对照组,CNV渗漏未消失(5.13%)、新增漏点概率(0)显著低于对照组,差异均有统计学意义(P<0.05)。治疗1、3个月后,观察组黄斑区视网膜和CNV复合体厚度均显著低于对照组,观察组复发率(12.80%)显著低于对照组(25.64%),差异有统计学意义(P<0.05)。结论:玻璃体腔内注射雷珠单抗+补肝益肾祛瘀汤治疗老年CNV疗效较好。
Objective: To explore the integrated traditional Chinese and western medicine and its clinical effects on senile macular degeneration (CNV). Methods: Seventy-eight patients with age-related macular degeneration (CNV) admitted to our hospital from January 2014 to January 2016 were randomly divided into control group and observation group, with 39 cases in each. The control group was treated with intravitreal injection of Lucentis. The observation group was treated with Bugan Yishen Quyu Decoction on the basis of the control group. The clinical efficacy, CNV leakage, macular retina and CNV complex thickness and postoperative recurrence 6 months. Results: The total effective rate in the observation group was 94.87%, significantly higher than that in the control group (74.36%). The CNV leakage in the observation group disappeared completely (23.08%), most of them disappeared (25.64%) and disappeared partially (46.15%), Compared with the control group, CNV leakage did not disappear (5.13%), and the new leak probability (0) was significantly lower than that of the control group (P <0.05). After 1 and 3 months of treatment, the thickness of retina and CNV complex in the macular area was significantly lower in the observation group than in the control group (12.80%, P <0.05), and the difference was statistically significant (P <0.05). Conclusion: Intravitreal injection of ranibizumab + Bugan Yishenquyu Decoction in elderly CNV is effective.