论文部分内容阅读
目的探讨婴幼儿难治性特发性血小板减少性紫癜(ITP)的治疗方法。方法检测所有血小板减少的住院婴幼儿的血小板相关抗体和血清细小病毒B19抗体;并将45例难治性ITP患儿随机分为治疗组与对照组。治疗组在应用激素的基础上使用干扰素和小剂量丙种球蛋白,对照组则在应用激素的基础上使用常规剂量丙种球蛋白。结果细小病毒B19抗体检出率在难治性ITP婴幼儿中明显增高;应用干扰素和小剂量丙种球蛋白的治疗组在激素使用时间、显效率、复发率等方面优于应用常规剂量的对照组,而血小板上升时间比较差异无统计学意义。结论婴幼儿难治性ITP的病因与细小病毒B19感染相关;干扰素与小剂量丙种球蛋白联合应用治疗ITP优于常规剂量的丙种球蛋白。
Objective To investigate the treatment of refractory idiopathic thrombocytopenic purpura (ITP) in infants and young children. Methods All platelet-associated antibodies and serum parvovirus B19 antibodies in hospitalized infants with thrombocytopenia were detected. Forty-five children with refractory ITP were randomly divided into treatment group and control group. The treatment group used interferon and low-dose gamma globulin based on the use of hormones while the control group used conventional doses of gamma globulin based on the use of hormones. Results The detection rate of parvovirus B19 antibody was significantly higher in refractory ITP infants and toddlers. The treatment with interferon and low-dose gamma globulin was superior to the conventional dose-control group in terms of hormone usage time, effective rate and relapse rate Group, while no significant difference in platelet rise time. Conclusions The etiopathogenisis of infantile refractory ITP is related to parvovirus B19 infection. The combination of interferon and low dose gamma globulin is superior to that of conventional dose of gamma globulin.