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在室温下,以取代苯酚1a-b和吡啶烷基醇2a-d为原料通过Mitsunobu反应合成了相应的芳基吡啶烷基醚,反应收率为45%￣70%,反应物2和1之比为1.11∶(摩尔比)。结果表明当酚的6-位取代基为甲氧基时,产物的收率比6-位上没有取代基时的收率高;溶剂对反应收率的影响不大。并用1H NMR、13C NMR和MS等对产物的结构进行了测定。
The corresponding arylpyridyl alkyl ethers were synthesized by the Mitsunobu reaction from the substituted phenol 1a-b and the pyridine alkyl alcohol 2a-d at room temperature. The yield of the reaction was 45% ~ 70%. The reaction products 2 and 1 The ratio was 1.11: (molar ratio). The results showed that when the 6-substituent of the phenol is methoxy, the yield of the product is higher than the yield of the product without substituent at the 6-position; the effect of the solvent on the yield of the reaction is not significant. The structure of the product was determined by 1H NMR, 13C NMR and MS.