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目的:探讨我市药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:对我市2003～2007年ADR监测中心收集到的4 806例ADR报告分别从年龄、给药途径、药品类别、临床表现等方面进行统计分析。结果:涉及ADR的药物品种逐年增加,其中抗感染药物居首位,以喹诺酮类、头孢菌素类和青霉素类所占的比例最大。给药方式以静脉为主,不良反应累及的系统以皮肤及其附件损害最多见。结论:临床应重视ADR的监测和报告工作。
Objective: To explore the characteristics and laws of adverse drug reaction (ADR) in our city and provide references for clinical rational drug use. Methods: A total of 4 806 ADR reports collected from ADR monitoring center in our city from 2003 to 2007 were statistically analyzed in terms of age, route of administration, drug category and clinical manifestations. Results: The varieties of drugs involved in ADR increased year by year, of which anti-infectives ranked first, and quinolones, cephalosporins and penicillins accounted for the largest proportion. The main mode of administration to the vein, adverse reactions involving the skin and its accessories to damage the most common. Conclusion: Clinical monitoring should focus on ADR and reporting.