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甲型肝炎病毒(HAV)是甲型病毒性肝炎(简称甲型肝炎)的病原体。一般以MS—1株作为甲型肝炎病毒的代表株。MS—1(Mir Seruml)是指曾患两次急性肝炎的患者Mir,在第一次患病出现黄疸前所采集的血清。接种这种血清可引起甲型肝炎。接种了MS-1株甲型肝炎病毒(MS—1株HAV)后发生肝炎的患者,血清中乙型肝炎表面抗原阴性,对乙型肝炎无交叉免疫性。 HAV在体外仍未能分离培养。近年来已发现与HAV有密切关系的甲型肝炎抗原(HAAg)颗粒,而且检测对甲型肝炎病毒的抗体(抗-HAV)也取得成功。甲型肝炎病原学研究前进了一大步。
Hepatitis A virus (HAV) is the causative agent of Hepatitis A virus (Hepatitis A). MS-1 strain is generally used as a representative of hepatitis A virus. MS-1 (Mir Seruml) refers to the serum collected before the onset of jaundice in Mir, a patient with two acute hepatitis. Inoculation of this serum can cause hepatitis A. Patients who developed hepatitis B after inoculation of the MS-1 strain of Hepatitis A virus (MS-1 strain HAV) had a negative serum hepatitis B surface antigen and no cross-immunity to hepatitis B virus. HAV still can not be isolated and cultured in vitro. In recent years, hepatitis A antigen (HAAg) particles that are closely related to HAV have been found, and the detection of antibodies against hepatitis A virus (anti-HAV) has also been successful. Hepatitis A etiology research is a big step forward.