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晚近的研究表明,充血性心衰(CHF)患者常伴不同程度的室心心律失常。一组701例CHF患者中,87％有室早二联律和/或室早多联律,54％有非持续性室速。故CHF患者的抗心律失常药的应用颇为普遍。但CHF所致的心输出量减少、组织灌注压下降和肝肾血流量的减少使抗心律失常药的药代动力学发生明显改变,同时抗心律失常药治疗范围甚窄,其本身又有致心律失常作用,有些兼有负性肌力作用,故抗心律失常药在CHF患者中更易发生毒性作用。关于CHF患者应用抗心律失常药治疗后猝死的
Recent studies have shown that patients with congestive heart failure (CHF) often have varying degrees of ventricular arrhythmias. A group of 701 patients with CHF, 87% had room early diplodysics and / or ventricular premature joint law, 54% have non-sustained ventricular tachycardia. Therefore, the anti-arrhythmic drugs in patients with CHF is quite common. However, decreased cardiac output due to CHF, decreased tissue perfusion pressure, and reduced hepatic and renal blood flow significantly altered the pharmacokinetics of anti-arrhythmic drugs, while the anti-arrhythmic drug treatment range was very narrow, which itself caused heart rhythm Lack of action, some with both negative muscle strength, so anti-arrhythmic drugs in patients with CHF more susceptible to toxic effects. About sudden death after CHF treatment in patients with antiarrhythmic drugs