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细胞外基质（ＥＣＭ）及多种细胞生长因子参与糖尿病性肾病的发病机制，这些细胞生长因子从不同的作用环节引起系膜细胞增生、系膜增殖、ＥＣＭ增多，从而导致糖尿病肾病的发生。
Extracellular matrix (ECM) and many kinds of cell growth factors are involved in the pathogenesis of diabetic nephropathy. These cell growth factors cause mesangial cell proliferation, mesangial proliferation and ECM increase from different action links, leading to the occurrence of diabetic nephropathy.