[目的]探索泰兴市HBsAg与其它危险因素致肝癌的交互作用。[方法]选择88例原发性肝癌新发病例按性别、年龄和居住地进行1∶1配对的病例对照研究 ,对全部研究对象检测了HBsAg和抗 HCV。[结果]病例组HBsAg和抗 HCV阳性率(72.73%和7.95%)显著高于对照(22.73%和1.13%) ,HBsAg阳性同时又暴露于慢性肝炎、性格忧郁、受过重大精神刺激及每次饮酒量多因素致肝癌发生的OR值分别为40.86、22.73、47.37和29.06,其两因素交互作用指数分别为0.7657、0.6364、0.8251和0.6469。[结论]泰兴市HBsAg与上述危险因素在致肝癌的关系中存在着显著的协同作用 [Objective] To explore the interaction between HBsAg and other risk factors of liver cancer in Taixing City. [Methods] Eighty-eight new cases of primary hepatocellular carcinoma (HCC) were selected for case-control study with sex, age, and place of residence. The HBsAg and anti-HCV were detected in all subjects. [Results] The positive rate of HBsAg and anti-HCV in the case group (72.73% and 7.95%) was significantly higher than that in the control (22.73% and 1.13%). HBsAg positive was also exposed to chronic hepatitis, personality depression, severe mental stimulation and alcohol consumption each time. The OR values ​​of liver cancer caused by multiple factors were 40.86, 22.73, 47.37, and 29.06, respectively. The two-factor interaction index was 0.7657, 0.6364, 0.8251, and 0.6469, respectively. [Conclusion] There is a significant synergy in the relationship between HBsAg in Taixing City and the above risk factors in hepatocellular carcinoma