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目的:分析医院药物不良反应发生的原因及其相关因素。方法:收集2015年8月—2016年7月间医院临床治疗中药物不良反应患者资料,采用回顾性分析法分析患者用药期间的临床表现、累及器官以及涉及的药物种类及给药途径等。结果:发生药物不良反应94例,其中65岁以上患者发生药物不良反应43例占45.74%高于其他年龄段患者;其累及消化系统症状的临床症状表现占51.06%高于其他累及器官的临床症状;抗菌药物类所致不良反应患者40例占42.55%;给药途径主要为静脉滴注用药占72.34%。结论:临床应积极采取预防措施,增强合理用药和安全用药意识,避免或减少不良反应的发生。
Objective: To analyze the causes of hospital adverse drug reactions and its related factors. Methods: The data of adverse drug reactions in clinical treatment of hospital from August 2015 to July 2016 were collected. The clinical manifestations, organ involvement, drug types and route of administration were analyzed retrospectively. Results: There were 94 cases of ADRs, of which 43 cases (45.74%) had ADRs and 45.74% were over 65 years old. The clinical symptoms of digestive system symptoms were 51.06% higher than those of other organs involved ; 40 cases of adverse reactions caused by antibacterial drugs accounted for 42.55%; the main route of administration for intravenous drip medication accounted for 72.34%. Conclusion: Clinical should take active preventive measures to enhance the rational use of drugs and safety awareness of medication to avoid or reduce the incidence of adverse reactions.