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用细粒棘球蚴 (Echinococcusgranulosus)原头节和多房棘球蚴 (Echinococcus multilocularis)原头节实验感染灰仓鼠(Cricetulusmigratorius)和草原兔尾鼠 (L agurus lagurus) ,并以 NIH小鼠和 BAL B/ c小鼠做对照 ,观察了继发性棘球蚴囊的发育情况。四种鼠的细粒棘球蚴感染率分别为 31% (37/ 118)、2 1% (6 / 2 8)、97% (30 / 31)和 89% (39/ 44 )。灰仓鼠和草原兔尾鼠继发囊发育远落后于 NIH小鼠和 BAL B/ c小鼠。灰仓鼠、草原兔尾鼠和 NIH小鼠对多房棘球蚴均可感染。灰仓鼠接种后第 2 5 d囊泡重量为 (0 .2 2± 0 .15 ) g,第 6 0 d为 (1.14± 0 .46 ) g,第 41d出现成熟原头节。草原兔尾鼠在接种后第 2 5 d囊泡重量为 0 .0 1g,第 6 0 d为 (0 .5 6± 0 .18) g,第 49d在组织切片和第 6 0 d在沉渣滴片中检出成熟原头节。作为对照的 NIH小鼠接种后直到第 90 d囊泡重量为 (0 .5 3± 0 .44 ) g,未查出成熟的原头节。实验证明灰仓鼠和草原兔尾鼠对多房棘球蚴十分敏感 ,在用于建立泡型包虫病的实验动物模型方面有独特优点。
Cricetulus migratorius and L agurus lagurus were experimentally infected with Echinococcus granulosus protoscoides and Echinococcus multilocularis protoscoleces. NIH mice and BAL B / c mice as control, observe the development of secondary echinococcosis sac. The infection rate of echinococcus granulosus of four kinds of mice was 31% (37/118), 21% (6/28), 97% (30/31) and 89% (39/44), respectively. Gray hamster and prairie young rats develop secondary lag behind NIH and BAL B / c mice. Gray hamsters, prairie rabbits and NIH mice were susceptible to multilocular echinococcosis. The weights of vesicles on the 25th day after inoculation were (0.22 ± 0.15) g and (1.14 ± 0.46) g on the 60th day, and mature protoscoleces appeared on the 41th day. At 20 days after inoculation, the weight of the vesicles was 0. 01g, and the 0th day was (0.56 ± 0.18) g on the 26th day after inoculation. On the 49th day, Detected in the film mature original head. NIH mice served as control did not detect mature protoscoleces until 90 days after inoculation with (0.53 ± 0.44) g vesicles. Experiments have shown that gray hamsters and prairie hamsters are very sensitive to Echinococcus multilocularis and have unique advantages in establishing experimental pupae models of experimental animals.