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目的观察中药开元冲剂对大鼠移植性子宫内膜异位的抑制作用。方法手术建立大鼠子宫内膜异位症动物模型,开元冲剂连续用药2周后处死大鼠剖腹,测量异位内膜体积并进行病理学检查。结果开元冲剂高剂量组(40 g/kg)和中剂量组(28.8 g/kg)用药后,异位内膜停止生长,体积变小,上皮变薄萎缩,腺体减少,与对照组比较差异有统计学意义(P<0.05)。结论在40 g/kg和28.8 g/kg剂量下,中药开元冲剂有抑制异位子宫内膜生长的作用。
Objective To observe the inhibitory effect of Kaiyuan Granules on transplanted endometriosis in rats. Methods Animal models of rat endometriosis were established by surgery. Kaiyuan Granules were sacrificed 2 weeks after the rats were sacrificed. Rats were sacrificed and their ectopic endometrial volume was measured and pathological examinations were performed. Results After administration of Kaiyuan Granules in high-dose group (40 g/kg) and middle-dose group (28.8 g/kg), ectopic intima stopped growing, the volume became smaller, epithelial thinning and atrophy, and glands decreased, compared with the control group. Statistically significant (P<0.05). Conclusion At the doses of 40 g/kg and 28.8 g/kg, Kaiyuan granules can inhibit the growth of ectopic endometrium.