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目的探讨过氧化物增值激活受体(PPAR)γ2基因多态性对高血糖人群膳食干预效果的影响。方法在南京主城区筛选241位高血糖汉族居民,设立干预组(129人)和对照组(112人),干预组给予粗杂粮馒头同时进行健康教育,对照组只进行健康教育,6个月进行一次体检,干预期为1a。结果干预组体质指数(BMI)、腰臀比(WHR)、空腹血糖(FBG)、胆固醇(TC)、甘油三酯(TG)比干预前降低(P<0.05),高密度脂蛋白胆固醇(HDL-C)升高(P<0.05);干预组干预后BMI、WHR、FBG、TC、TG低于对照组(P<0.05),HDL-C高于对照组(P<0.05)。无论Pro/Pro基因型还是Pro/Ala基因型人群,干预后体重、BMI、FBG、TC、TG均比干预前降低(P<0.05);Pro/Ala基因型人群体重、BMI、TG的下降幅度大于Pro/Pro型人群(P<0.05)。结论复合式膳食干预对高血糖人群具有良好的效果;Pro/Ala基因型人群干预效果好于Pro/Pro基因型人群。
Objective To investigate the effects of PPARγ2 polymorphism on dietary intervention in hyperglycemic subjects. Methods A total of 241 residents with hyperglycemic Han nationality were screened in the main urban area of Nanjing. Intervention group (129 persons) and control group (112 persons) were enrolled. The intervention group was given coarse cereals bread and health education at the same time. The control group received health education only for 6 months A physical examination, the intervention period of 1a. Results The body mass index (BMI), WHR, FBG, TC and triglyceride in the intervention group were lower than those before intervention (P <0.05), while the levels of high density lipoprotein cholesterol (P <0.05). The levels of BMI, WHR, FBG, TC and TG in intervention group were lower than those in control group (P <0.05) and HDL-C was higher than that in control group (P <0.05). The body weight, BMI, FBG, TC and TG in intervention group were significantly lower than those in intervention group (P <0.05), Pro / Pro genotype and Pro / Ala genotype, Greater than Pro / Pro population (P <0.05). Conclusions The composite dietary intervention has a good effect on hyperglycemic population; the effect of Pro / Ala genotype intervention is better than Pro / Pro genotype population.