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目的探讨莫沙必利与奥美拉唑联合治疗反流性食管炎(RE)的临床疗效。方法36例RE患者餐前30min口服莫沙必利5mg,3次/d,奥美拉唑20mg,1次/d,共8周。结果4周后,显效率41.67%(15/36),有效率69.44%(25/36),8周后显效率80.56%(29/36),有效率100%(36/36)。治疗前后比较,8周显效率、有效率均优于4周者,有显著性差异(P<0.01)。结论莫沙必利与奥美拉唑联合治疗反流性食管炎疗效显著。
Objective To investigate the clinical efficacy of mosapride and omeprazole in the treatment of reflux esophagitis (RE). Methods 36 patients with RE were orally given mosapride 5 mg orally 3 times daily for 10 minutes and omeprazole 20 mg orally for 8 weeks. Results After 4 weeks, the effective rate was 41.67% (15/36), the effective rate was 69.44% (25/36). After 8 weeks, the effective rate was 80.56% (29/36) and the effective rate was 100% (36/36). Before and after treatment, 8 weeks significantly efficiency, effective rate was better than 4 weeks, there was a significant difference (P <0.01). Conclusion Mosapride and omeprazole combined treatment of reflux esophagitis significant effect.