目前膀胱癌诊断及随访主要依靠尿细胞学检查与膀胱镜检相结合的手段,现有方法不仅费用较昂贵,同时为患者带来较大的痛苦。尿液作为无创标本,可提供蛋白质、RNA及DNA来源,是膀胱癌理想的肿瘤标记物。近年来,有较多研究关注于尿液中膀胱癌肿瘤标记物的应用。本文主要概述了现有的尿液中膀胱癌肿瘤标志物的研究进展,并讨论其存在的不足及研究前景。 At present, the diagnosis and follow-up of bladder cancer mainly rely on the combination of urinary cytology and cystoscopy. The existing methods are not only more expensive but also cause more pain for the patients. As a noninvasive specimen, urine can provide protein, RNA and DNA sources and is an ideal tumor marker for bladder cancer. In recent years, more studies have focused on the use of bladder cancer tumor markers in urine. This article mainly summarizes the existing research progress of bladder cancer tumor markers in urine and discusses its shortcomings and research prospects.