论文部分内容阅读
目的了解广州地区妇女生殖道人乳头状瘤病毒感染状况和基因亚型分布。方法 2006年10月至2010年2月,采用核酸分子快速导流杂交基因芯片分型技术(HybriMax)对广州地区6493例女性进行人乳头状瘤病毒检测,并对HPVDNA亚型、感染率和年龄分布进行分析。结果 6493例女性中检出HPV阳性1947例,阳性率为29.99%。阳性感染者中,单一型感染最多,为1436例,占73.75%,其中高危单一型感染者1143例,占58.71%,低危单一型感染者293例,占15.05%;混合型感染者511例,占26.25%,主要为双重感染,占19.41%。15个与宫颈癌密切相关的HPV高危亚型阳性率为25.24%,6个低危亚型HPV感染阳性率为7.98%。排在前十位的亚型分别是HPV52(25.22%)、HPV58(14.20%)、HPV16(13.56%)、HPV6(9.76%)、HPV11(8.32%)、HPV53(7.70%)、HPV33(6.73%)、CP8304(6.68)、HPV68(6.63)、HPV18(6.52%)。在各年龄组中,小于20岁女性感染率最高,为52.5%,各年龄组HPV感染差异有统计学意义(χ2=17.926,P<0.05)。不同来源患者的HPV阳性率分别是30.66%,19.24%,28.24%,35.92%,差异有统计学意义(χ2=23.274,P<0.05)。结论广州地区女性有相当高比例的HPV感染,HPV52、58、16、6亚型是最主要的感染亚型,进行HPVDNA检测和分型对宫颈病变的防治具有重要意义。
Objective To understand the prevalence and distribution of human papilloma virus (HPV) in reproductive tract of women in Guangzhou. Methods From June 2006 to February 2010, 6493 women in Guangzhou area were tested for HPV by HybriMax. The prevalence of HPVDNA subtypes, infection rate and age Distribution for analysis. Results A total of 1947 HPV positive cases were detected in 6493 women, the positive rate was 29.99%. Among the positive infections, the single infection was the most, which was 1436 cases, accounting for 73.75%. Among them, 1143 cases were high risk single infection, accounting for 58.71%; 293 cases were low risk single infection, accounting for 15.05%; mixed infection was 511 cases , Accounting for 26.25%, mainly double infection, accounting for 19.41%. The positive rates of HPV high-risk subtypes in 15 cases closely related to cervical cancer were 25.24%, and the positive rates of HPV in 6 low-risk subtypes were 7.98%. The top 10 subtypes were HPV52 (HPV) (14.20%), HPV16 (13.56%), HPV6 (9.76%), HPV11 (8.32%), HPV53 ), CP8304 (6.68), HPV68 (6.63), HPV18 (6.52%). Among all age groups, women younger than 20 years old had the highest infection rate of 52.5%. There was a significant difference in HPV infection among all age groups (χ2 = 17.926, P <0.05). The positive rates of HPV in patients of different origins were 30.66%, 19.24%, 28.24% and 35.92%, respectively. The difference was statistically significant (χ2 = 23.274, P <0.05). Conclusions There is a high proportion of HPV infection among women in Guangzhou. HPV52, 58, 16 and 6 subtypes are the most important subtypes of infection. It is of great significance to detect and classify HPV DNA for the prevention and treatment of cervical lesions.