自1975年kohler和Milstein成功地研制了具有定向特异性的单克隆抗体(简称单抗)技术以来,人们就意识到,制备人的单克隆抗体(人单抗)已为期不远了。人单抗可克服鼠类单抗用于人体之后所产生的各种弊端,为人类疾病的诊断、肿瘤的体内诊断与治疗、自身免疫性疾病与变态反应性疾病的治疗、体内稀有抗原的研究、药物的追踪等提供了理想的手段。各国学者为制备人单抗,探索了众多的 Since 1975, Kohler and Milstein successfully developed a monoclonal antibody with orientation specificity (referred to as monoclonal antibody) technology, it is recognized that the preparation of human monoclonal antibodies (mAbs) is not far off. Human monoclonal antibody can overcome the various disadvantages of the mouse monoclonal antibody for the human body after the human for the diagnosis of human disease, in vivo diagnosis and treatment of tumors, autoimmune diseases and allergic diseases, rare in vivo antigen research , Drug tracking provides the ideal means. National scholars for the preparation of human monoclonal antibody, to explore a large number