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DNA修复能力增强是导致肿瘤细胞对化疗产生耐药的原因之一,DNA修复存在5种途径,包括同源重组修复、非同源末端连结、核苷酸切除修复、碱基切除修复和错配修复。研究显示,DNA修复相关基因蛋白如BRCA1,ERCC1,XPD,XRCC1和hMLH1等与卵巢癌化疗耐药相关联。DNA修复相关基因单核苷酸多态性与肿瘤患者对化疗药物的敏感程度和预后有关,有助于预测化疗反应性。
One of the reasons leading to the resistance of tumor cells to chemotherapy is the enhancement of DNA repair ability. There are five ways of DNA repair, including homologous recombination repair, non-homologous end joining, nucleotide excision repair, base excision repair and mismatch repair. Studies have shown that DNA repair-related gene proteins such as BRCA1, ERCC1, XPD, XRCC1 and hMLH1 are associated with chemoresistance in ovarian cancer. Single nucleotide polymorphisms in DNA repair-related genes are associated with the sensitivity and prognosis of chemotherapeutic drugs in cancer patients, which is helpful to predict the response to chemotherapy.