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目的:分析急性心肌梗死患者急性期NT-proBNP水平与Killip心功能分级的相关性,评价NT-proBNP的高低和患者预后的关系。方法:选择本科室临床诊断为急性心肌梗死的既往患者40例,男28例女12例,平均年龄62岁,其中急性非ST段抬高心肌梗死15例,急性ST段抬高心肌梗死25例,急性期按Killip分级标准心功能分为4组,预后(住院1个月)分析按急性期NT-proBNP值分为3组,分别为NT-proBNP《300vg/ml(A组),300vg/ml》NT-proBNP《5000vg/ml(B组),NT-proBNP》5000vg/ml(C组)。分析比较各组间Killip心功能分级级别,EF值,与发生心力衰竭或死亡等预后的关系。结果:血清NTproBNP浓度与心功能状态呈负相关,NT-proBNP浓度升高组的心血管事件(心力衰竭、死亡等)发生率明显升高,差异有统计学意义。结论:检测血清NT-proBNP浓度可以结合EF值了解急性心肌梗死患者的心功能状态,评估患者的近期预后。
OBJECTIVE: To analyze the correlation between NT-proBNP level and Killip’s cardiac function in patients with acute myocardial infarction and to evaluate the relationship between the level of NT-proBNP and the prognosis of patients. Methods: Forty patients with acute myocardial infarction in our department were enrolled. Among them, there were 12 males and 28 females with a mean age of 62 years. There were 15 cases of acute non-ST segment elevation myocardial infarction, 25 cases of acute ST elevation myocardial infarction The acute phase was divided into 4 groups according to the Killip grading standard heart function. The prognosis (hospitalization 1 month) analysis was divided into 3 groups according to the acute NT-proBNP value: NT-proBNP 300vg / ml (group A), 300vg / ml “NT-proBNP” 5000vg / ml (group B) and NT-proBNP "5000vg / ml (group C). Analysis and comparison of Killip heart function grading level between groups, EF value, and the occurrence of heart failure or death and other prognosis. Results: The serum concentration of NTproBNP was negatively correlated with the state of cardiac function. The incidence of cardiovascular events (heart failure, death, etc.) was significantly increased in NT-proBNP group with statistically significant difference. Conclusion: Detecting serum NT-proBNP concentration can be combined with EF value to understand the state of cardiac function in patients with acute myocardial infarction to assess the patient’s immediate prognosis.