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锌离子在生物体系中扮演着重要角色,其分析和检测在疾病诊断和医疗检测等方面具有重要价值。用于Zn2+检测的荧光传感器具有检测方便、灵敏度高等优点,引起了广泛关注。典型的荧光传感器通常是由识别基团和作为报告单元的荧光团通过间隔基团或直接连接而组成的。识别基团是荧光传感器的作用核心,在高选择性识别过程中起着至关重要的作用。自1996年第一次接在荧光素上以来,DPA(N,N-二(2-吡啶甲基)胺,di-2-picolylamine)基团在锌离子传感器的设计中得到了广泛应用。本文综述了近年来文献中报道的基于DPA识别基团的锌离子传感器,介绍了锌离子荧光传感器的合成方法与识别原理,最后简单介绍了锌离子传感器中其它几种常见的识别基团。
Zinc ions play an important role in biological systems, and their analysis and detection are of great value in disease diagnosis and medical testing. Fluorescent sensor for Zn2 + detection has the advantages of convenient detection and high sensitivity, arousing widespread concern. Typical fluorescent sensors are usually composed of a recognition group and a fluorophore as a reporter unit, either via a spacer group or directly attached. Recognition groups are the core of fluorescence sensors and play a crucial role in highly selective recognition. DPA (N, N-bis (2-picolyl) amine, di-2-picolylamine) groups have been widely used in the design of zinc ion sensors since they were attached to fluorescein for the first time in 1996. This review summarizes the zinc ion sensors based on DPA recognition groups reported in the literature in recent years, introduces the synthesis method and recognition principle of zinc ion fluorescence sensors, and then briefly introduces several other common recognition groups in zinc ion sensors.