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目的:观察β受体激动剂与抗胆碱能药物治疗COPD的临床疗效。方法:选择我院自2010年2月至2014年2月收治的480例COPD患者的临床资料,根据随机的原则,将患者分为治疗组240例与对照组240例,全部患者给予相同的基础治疗。对照组患者在基础治疗的基础上,加用沙丁胺醇、生理盐水空气压缩雾化吸入法治疗,治疗组患者在基础治疗的基础上,联合应用沙丁胺醇、异丙托溴铵、生理盐水空气压缩雾化吸入治疗。结果:两组患者咳嗽、喘息缓解及肺部哮鸣音消失时间对比,结果具有显著性差异(P<0.05),两组患者临床有效率比较,结果具有显著性差异(P<0.05)。结论:采用β受体激动剂与抗胆碱能药物治疗COPD具有起效快、疗效好、安全等特点,可临床推广应用。
Objective: To observe the clinical efficacy of β-agonists and anticholinergic drugs in the treatment of COPD. Methods: The clinical data of 480 COPD patients admitted to our hospital from February 2010 to February 2014 were selected. According to the randomized principle, 240 patients were divided into treatment group (240 cases) and control group (240 cases), all patients were given the same basis treatment. Patients in the control group were treated with salbutamol and saline compressed air atomizing inhalation on the basis of basic treatment. Patients in the treatment group were treated with salbutamol, ipratropium bromide and saline air compression atomization Inhalation therapy. Results: There was a significant difference between the two groups in the time of cough and wheeze relief and the disappearance time of lung wheeze (P <0.05). There was significant difference between the two groups in clinical efficiency (P <0.05). Conclusion: The use of β-agonists and anticholinergic drugs in the treatment of COPD has the characteristics of quick onset, good curative effect, safety and so on, and can be clinically popularized and applied.