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目的研究血清白细胞介素(IL)-8水平和外周血白细胞(WBC)总数与冠心病病情及冠状动脉病变程度的关系。方法分为3组:急性心肌梗死(AMI)组100例、不稳定性心绞痛(UAP)组100例、稳定性心绞痛(SAP)组96例和对照组100例。用酶联免疫吸附试验检测各组血清IL-8的水平,并比较各组间的差异。结果 AMI组、UAP组及SAP组的血清IL-8水平均高于对照组(P<0.05);AMI组、UAP组IL-8水平明显高于SAP组;AMI组和UAP组结果相似;冠心病患者血清IL-8与外周血WBC总数变化呈正相关。结论血清IL-8升高可能是老年冠状动脉粥样硬化的标志,参与了冠心病的发病过程,血清IL-8水平与冠状动脉病变程度密切相关。
Objective To investigate the relationship between serum interleukin (IL) -8 level and the total number of peripheral white blood cells (WBC) and the severity of coronary heart disease and coronary artery disease. Methods The patients were divided into three groups: 100 in AMI group, 100 in unstable angina pectoris group, 96 in SAP group and 100 in control group. Serum levels of IL-8 were detected by enzyme-linked immunosorbent assay (ELISA), and the differences between groups were compared. Results Serum levels of IL-8 in AMI, UAP and SAP groups were significantly higher than those in control group (P <0.05). The levels of IL-8 in AMI group and UAP group were significantly higher than those in SAP group. The results of AMI group and UAP group were similar. Heart disease patients with serum IL-8 and the total number of peripheral WBC changes was positively correlated. Conclusions Elevated serum IL-8 may be a marker of coronary atherosclerosis in elderly patients. It is involved in the pathogenesis of coronary heart disease. Serum IL-8 level is closely related to the severity of coronary artery disease.