研究了西咪替丁与氯醌酸的荷移反应。确定了形成电荷转移络合物的最佳反应条件。在丙酮介质中,电子给体西咪替丁与电子受体氯醌酸于室温下可形成1:1的荷移络合物,络合物的最大吸收波长为516.6nm;表观摩尔吸光系数ε=2.22×103L.mol-1.cm-1;线性范围为6.8—112.0μg/mL;相关系数r为0.9995;并对形成荷移络合物的反应机理进行了探讨,并应用拟定的方法对样品西咪替丁片剂进行了含量测定,回收率为99.44%—100.20%;RSD为1.3%。 The charge-transfer reaction of cimetidine with chloranilic acid was studied. The optimal reaction conditions for forming charge-transfer complexes were determined. In acetone medium, the electron donor cimetidine and the electron acceptor chloranil acid form a 1: 1 charge-transfer complex at room temperature. The maximum absorption wavelength of the complex is 516.6 nm. The apparent molar absorptivity ε = 2.22 × 103L.mol-1.cm-1; the linear range was 6.8-112.0μg / mL; the correlation coefficient r was 0.9995; and the reaction mechanism of charge-forming complexes was discussed. The content of cimetidine tablets was determined. The recovery rate was 99.44% -100.20%. The RSD was 1.3%.