环氧化酶(COX)2作为体内前列腺素生物合成的限速酶,是催化花生四烯酸转化为前列腺素的关键酶,COX至少存在两种同工酶:COX-1(结构型)和COX-2(诱导型),近年来还发现有COX-3,但还存在争议。肝癌是我国位居第二的恶性肿瘤,病死率高,预后差。目前研究表明,大多数恶性肿瘤的发生与某些特定基因的改变密切相关。现主要就COX-2在肝癌中的研究进展予以综述。 Cyclooxygenase (COX) 2, as a rate-limiting enzyme for prostaglandin biosynthesis in vivo, is a key enzyme that catalyzes the conversion of arachidonic acid to prostaglandins. There are at least two isozymes in COX: COX-1 (structural) and COX-2 (inducible), in recent years also found COX-3, but there are still controversial. Liver cancer is the second malignant tumor in China, with high mortality and poor prognosis. The current research shows that the occurrence of most malignant tumors is closely related to the changes of some specific genes. The main research progress of COX-2 in hepatocellular carcinoma is reviewed.