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目的回顾性分析血浆灌流在难治型高胆红素血症治疗中的应用效果。方法对39例高胆红素血症患者在内科综合治疗基础上加用人工肝支持系统中的血浆灌流进行治疗,39例患者共计进行112例次治疗,平均2～4次。每次治疗前后检测肝功能、凝血酶原活动度、血小板、及血氨等生化指标,并观察临床症状、体征的变化。结果治疗后患者的症状减轻,肝功能、凝血酶原活动度、血氨有不同程度的改善,经统计学处理有显著意义(P<0.05)。结论血浆灌流治疗可改善难治型高胆红素血症患者临床症状及生化指标,提高疗效。
Objective To retrospectively analyze the effect of plasma perfusion in the treatment of refractory hyperbilirubinemia. Methods Thirty-nine patients with hyperbilirubinemia were treated with plasma perfusion in the artificial liver support system on the basis of comprehensive medical treatment. A total of 112 patients were treated with 112 patients in an average of 2 to 4 times. Before and after each treatment, liver function, prothrombin activity, platelets, blood ammonia and other biochemical parameters were detected, and the changes of clinical symptoms and signs were observed. Results After treatment, the symptom relief, hepatic function, prothrombin activity and blood ammonia were improved to some extent, which were statistically significant (P <0.05). Conclusion Plasma perfusion therapy can improve the clinical symptoms and biochemical indexes in patients with refractory hyperbilirubinemia and improve the curative effect.