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目的探讨糖皮质激素在治疗结核性胸膜炎过程中的疗效和对炎症细胞因子的影响。方法 88例结核性胸膜炎患者,随机分为对照组和观察组,每组44例。对照组接受常规化疗方案联合胸穿抽液治疗,观察组在对照组基础上加用糖皮质激素治疗,分析两组患者治疗疗效和对炎性细胞因子的影响。结果观察组患者治疗有效率和白介素-6(IL-6)、白介素-8(IL-8)等炎性细胞因子水平均明显优于对照组,差异具有统计学意义(P<0.05)。结论在常规化疗方案联合胸穿抽液治疗的基础上加用糖皮质激素治疗结核性胸膜炎可以提高临床治疗的有效率,降低IL-6、IL-8水平,可以抑制胸腔局部免疫细胞,值得临床推广和运用。
Objective To investigate the effects of glucocorticoids on inflammatory cytokines in the treatment of tuberculous pleurisy. Methods 88 cases of tuberculous pleurisy were randomly divided into control group and observation group, 44 cases in each group. The control group received routine chemotherapy combined with chest draining fluid treatment. The observation group was treated with glucocorticoid on the basis of the control group, and the curative effect and the influence on the inflammatory cytokines in the two groups were analyzed. Results The effective rate of treatment and the levels of inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-8 (IL-8) in the observation group were significantly better than those in the control group, with statistical significance (P <0.05). Conclusion The combination of conventional chemotherapy combined with thoracentesis treatment with glucocorticoid treatment of tuberculous pleurisy can improve the efficiency of clinical treatment, reduce the level of IL-6, IL-8, can inhibit the local immune cells in the chest, it is worth clinical Promote and use.