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目的研究前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的临床效果。方法 70例糖尿病肾病患者,将其随机分为观察组与对照组,各35例,对照组患者进行常规胰岛素降糖、抗凝、降压治疗。观察组患者在对照组治疗基础上再使用前列地尔、贝那普利。治疗后比较两组患者不良反应及尿蛋白含量。结果两组患者治疗前24 h尿微量白蛋白排泄率及24 h尿蛋白含量比较,差异无统计学意义(P>0.05)。两组患者在接受治疗后,两组患者24 h尿蛋白含量与治疗前相比,有显著的降低,差异有统计学意义(P<0.05),观察组24 h尿蛋白含量减少量较对照组更为明显,比较差异有统计学意义(P<0.05)。两组患者24 h尿微量白蛋白排泄率均有明显降低,差异有统计学意义(P<0.05),观察组患者24 h尿微量白蛋白排泄率降低较对照组更为明显,比较差异有统计学意义(P<0.05)。观察组35例患者中,2例患者出现皮肤发红,1例患者出现干咳。对照组35例患者中,3例患者出现头痛症状。两组患者症状均自行好转,均未出现严重不良反应。结论前列地尔与贝那普利联合使用治疗糖尿病肾病蛋白尿患者,能够有效的降低尿蛋白水平,患者术后并发症较少,对糖尿病肾病蛋白尿治疗效果较为理想。
Objective To study the clinical efficacy of alprostadil combined with benazepril in the treatment of diabetic nephropathy proteinuria. Methods Seventy patients with diabetic nephropathy were randomly divided into observation group and control group, 35 cases in each group. Patients in control group were treated with regular insulin hypoglycemic, anticoagulation and antihypertensive treatment. Patients in observation group were treated with alprostadil and benazepril on the basis of the control group. Adverse reactions and urinary protein content were compared between the two groups after treatment. Results There was no significant difference in urinary albumin excretion rate and 24 h urinary protein content between the two groups before treatment (P> 0.05). After treatment, the 24-hour urinary protein levels in both groups were significantly lower than those before treatment (P <0.05), and the decrease in 24-hour urinary protein in the two groups was significantly lower than that in the control group More obvious, the difference was statistically significant (P <0.05). Urine microalbumin excretion rate in 24 hours and 24 hours in both groups were significantly lower (P <0.05), the urinary albumin excretion rate in 24 hours in observation group was more obvious than that in control group Significance (P <0.05). Of the 35 patients in the observation group, 2 developed redness in the skin and 1 developed dry cough. Among 35 patients in the control group, 3 patients had headache symptoms. Symptoms in both groups improved on their own, did not appear serious adverse reactions. Conclusion The combination of alprostadil and benazepril in the treatment of diabetic nephropathy patients with proteinuria can effectively reduce the level of urinary protein in patients with less postoperative complications, the therapeutic effect of diabetic nephropathy proteinuria is more ideal.