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目的探讨肿瘤坏死因子超家族成员4(TNFSF4)基因SNP rs3850641与湖南地区脑梗死发病风险的关系。方法采用TaqMan-PCR方法检测TNFSF4基因SNP rs3850641基因型与等位基因频率。湖南藉汉族脑梗死284例,309例匹配的对照组进行关联研究。结果脑梗死组和对照组各基因型(χ2=3.551,P=0.169)和等位基因频率(χ2=3.261,P=0.071)组间分布无显著性差异;两种脑梗死亚型与对照组之间基因型和等位基因频率分布无统计学差异(P>0.05);男性CI组G等位基因频率明显低于对照组,有统计学意义(χ2=5.993,P<0.05)。Logistic多因素回归分析显示rs3850641各基因型没有使脑梗死发病的危险增加。结论TNFSF4基因SNP rs3850641可能不增加湖南地区脑梗死的发病风险。
Objective To investigate the relationship between SNP rs3850641 in tumor necrosis factor superfamily 4 (TNFSF4) gene and the risk of cerebral infarction in Hunan province. Methods The genotype and allele frequency of TNFSF4 SNP rs3850641 were detected by TaqMan-PCR. In Hunan, 284 cases of cerebral infarction and 309 cases of matched controls were studied. Results There was no significant difference in genotype distribution between the cerebral infarction group and the control group (χ2 = 3.551, P = 0.169) and allele frequency (χ2 = 3.261, P = 0.071) (P> 0.05). The frequency of G allele in male CI group was significantly lower than that in control group (χ2 = 5.993, P <0.05). Logistic multivariate regression analysis showed that rs3850641 genotypes did not increase the risk of cerebral infarction. Conclusion TNFSF4 gene SNP rs3850641 may not increase the risk of cerebral infarction in Hunan.