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为观察消炎痛关闭新生儿(足月儿及早产儿)动肪导管未闭(PDA)的效果,对经心脏彩超确诊的新生儿PDA 90例,其中72例(足月儿33例,早产儿39例)口服消炎痛治疗,另18例未用消炎痛作为对照组。结果显示,消炎痛治疗组动脉导管关闭率明显高于对照组;其中早产儿关闭率(92.37％)高于足月儿(78.78％),并明显高于对照组(92.37％比42.8％);足月儿用药组与对照组相比无明显差异。消炎痛治疗组中有21例合并其他先心病,结果单纯PDA导管关闭率(94.12％)明显高于合并其他先心病的PDA组(61.9％)。早产儿动脉导管的自闭率低于足月儿。结论:口服消炎痛治疗早产儿PDA的效果优于足月儿,单纯PDA优于合并其他先心病者,足月儿在治疗原发病后PDA自闭的可能性大,早产儿自闭的可能性相对较小。
To observe the effect of indomethacin on neonatal (full-term and premature infants) closed duodenal catheterization (PD), 90 neonatal PDA diagnosed by echocardiography, of which 72 (33 full-term infants, 39 preterm infants Example) oral indomethacin treatment, and the other 18 cases did not use indomethacin as a control group. The results showed that the closure rate of patent ductus arteriosus in indomethacin treatment group was significantly higher than that in control group. The closure rate of preterm infants (92.37%) was higher than that of term infants (78.78%) and significantly higher than that of control group (92.37% versus 42.8%). There was no significant difference in full-term children medication group compared with control group. Indomethacin treatment group, 21 patients with other congenital heart disease, the results of simple PDA catheter closure rate (94.12%) was significantly higher than those with other congenital heart disease PDA group (61.9%). Arterial catheters in preterm infants have a lower autistic rate than full-term infants. Conclusion: The effect of oral indomethacin on PDA in premature infants is better than that of full-term infants. The simple PDA is better than other patients with congenital heart disease. The full-term infants are more likely to become autistic after PDA. Sex is relatively small.