近年来,国内外对于难治性癫癎发病机制的研究已经证实,多药耐药基因(MDR)在癫癎病灶内存在异常高表达现象,这种高表达可能通过一种非特异性的机制将一部分结构与其底物类似的化合物,包括大部分抗癫癎药(AEDs),从其作用部位排出,造成局部药物的有效浓度降低,使癫癎发作难以控制。导致多药耐药基因1(MDR1)表达增加的原因还不清楚,可能是多方面的,绝大多数作者认为癫癎长期反 In recent years, the research on the pathogenesis of refractory epilepsy both at home and abroad has confirmed that there is an abnormally high expression of multidrug resistance gene (MDR) in epileptic lesions. This high expression may be mediated by a nonspecific mechanism Part of the structure of its substrate similar compounds, including most of the anti-epileptic drugs (AEDs), excreted from the site of action, resulting in the effective concentration of local drugs to reduce the epileptic seizures difficult to control. The reasons leading to the increased expression of multidrug resistance gene 1 (MDR1) are unclear and may be multifaceted. The vast majority of authors believe that long-term anti-epilepsy