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肝脏是人体最大的消化腺,也是最主要的代谢器官。自20世纪60年代,人们在肝脏溶酶体的研究中提出“自噬”这一概念时,就发现肝脏内的营养水平与激素影响自噬活动。近年来的研究表明,自噬不仅是正常的生理过程,也参与许多病理过程的调节。本文介绍了自噬在健康肝脏中维持稳态的作用,旨在为肝脏生理学及自噬失调相关疾病的治疗提供新思路。
The liver is the body’s largest digestive gland, is also the most important metabolic organ. Since the 1960s, when people proposed the concept of “autophagy” in the study of hepatic lysosomes, it was found that the level of nutrition and hormones in the liver affected the autophagy activity. In recent years, studies have shown that autophagy is not only a normal physiological process, but also involved in the regulation of many pathological processes. This article describes the role of autophagy in maintaining a steady state in healthy livers and aims to provide new insights into the treatment of disorders associated with liver physiology and autophagy.