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选择健康人40例及我院住院2型糖尿病病人110人,根据24小时尿白蛋白定量分为糖尿病无肾病组(A组)、早期肾病组(B组)及临床期肾病组(C组),全部病人测定血甘油三脂(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB),将各组指标分析比较。结果:B组、C组病人血TG较A组病人升高更明显,TC较正常组升高(P<0.05),A组、B组、C组HDL-C均有下降,而B组、C组下降更有意义(P<0.01).B组、C组血LDL-C较A组升高,有统计学意义,B组、C组血ApoA1下降,ApoB升高,ApoB/ApoA1升高。结论:糖尿病肾病病人血脂及载脂蛋白显著异常,对糖尿病合并早期及临床期肾病病人应严格控制血脂水平。
Forty healthy people and 110 hospitalized patients with type 2 diabetes mellitus were enrolled in this study. According to 24-hour urine albumin, they were divided into diabetic nephropathy group (group A), early nephropathy group (group B) and clinical nephropathy group (group C) All the patients were tested for triglyceride (TG), cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), the indicators of each group analysis and comparison. Results: The blood TG of patients in group B and group C were significantly higher than that of patients in group A, TC was significantly higher than that of normal group (P <0.05), HDL-C of group A, B and C were decreased, (P <0.01). The blood LDL-C levels in group B and group C were significantly higher than those in group A, and the levels of ApoA1, ApoB and ApoB / ApoA1 in group B and group C were significantly lower . Conclusion: The levels of serum lipids and apolipoprotein in patients with diabetic nephropathy are significantly abnormal. Serum lipid levels should be strictly controlled in diabetic patients with early and clinical nephropathy.