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本文报导了以4′-去甲表鬼臼素-4-β-D-葡萄糖甙分别与二甲醇缩乙醛和噻吩甲醛反应合成抗肿瘤药物依托泊甙(Vp-16)和替尼泊甙(Vm-26)中得到的两个主要副产物Vp-x和Vm-x的结构鉴定,并对其反应机理进行了探讨。
This paper reports the synthesis of antitumor drugs etoposide (Vp-16) and teniposide with 4’-nor-epipodophyllotoxin-4-β-D-glucoside with dimethylacetal and thiophene- (Vm-26) obtained in the two major byproducts Vp-x and Vm-x structure identification, and its reaction mechanism were discussed.