原发性滤泡性免疫母细胞淋巴瘤(FIBL)是种极少见的淋巴瘤,其免疫表型CD10阳性提示起源于生发中心,而CD138阳性说明伴有浆母/浆细胞分化。为了更好地诊疗此病,本文从临床病理和免疫表型的特点方面报道国内首例女性患者,行PET-CT检查明确全身淋巴结的累及情况,并分别与滤泡性淋巴瘤、反应性滤泡增生作鉴别诊断。FIBL作为滤泡性淋巴瘤的罕见变异型,表现为滤泡内的肿瘤性免疫母细胞过度增生,向弥漫性大B细胞淋巴瘤的转化率略高于滤泡性淋巴瘤,预后较差,应予重视。 Primary follicular immunoblastic lymphoma (FIBL) is a rare form of lymphoma whose immunophenotype CD10-positive suggests originating in the germinal center whereas CD138-positive is associated with plasma / plasma cell differentiation. In order to diagnose the disease better, this paper reports the first case of female patients from the clinicopathological and immunophenotypic characteristics of the case, the line of PET-CT examination of clear systemic lymph node involvement, and were associated with follicular lymphoma, reactive filter Bubble proliferation for the differential diagnosis. As a rare variant of follicular lymphoma, FIBL is characterized by hyperplasia of tumorous immunoblasts in the follicular, a slightly higher rate of conversion to diffuse large B-cell lymphoma than that of follicular lymphoma, a poor prognosis, Should be valued.