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AIM:To investigate the utility of phosphorus-31(31P)magnetic resonance spectroscopy(MRS)as a noninvasive test for assessment of response to interferon and ribavirin treatment in patients with different severities of hepatitis C virus infection.METHODS:Sixty chronic hepatitis C patients undergoing antiviral therapy with interferon and ribavirin underwent 31P MRS at 3.0T before treatment,6 mo after the start of treatment,and 1 year after the start of treatment.RESULTS:The phosphomonoester(PME)/phosphodiester(PDE)ratio at 6 mo after the start of antiviral therapy in the Child-Pugh B and C groups were significantly higher than those before therapy,but this was not seen in the Child-Pugh A group.In the antiviral therapy group,the PME/PDE ratios had decreased on follow-up MR spectroscopy.However,in the virological nonresponder group,the PME/PDE ratios on follow-up imaging were similar to the baseline values.CONCLUSION:31P MRS can be used to provide biochemical information on hepatic metabolic processes.This study indicates that the PME/PDE ratio can be used as an indicator of response to antiviral treatment in chronic hepatitis C patients.
A To investigate the utility of phosphorus-31 (31P) magnetic resonance spectroscopy (MRS) as a noninvasive test for assessment of response to interferon and ribavirin treatment in patients with different severities of hepatitis C virus infection. METHODS: Sixty chronic hepatitis C patients undergoing antiviral therapy with interferon and ribavirin underwent 31P MRS at 3.0T before treatment, 6 months after the start of treatment, and 1 year after the start of treatment.RESULTS: The phosphomonoester (PME) / phosphodiester (PDE) ratio at 6 months after the start of antiviral therapy in the Child-Pugh B and C groups were significantly higher than those before therapy, but this was not seen in the Child-Pugh A group. the antiviral therapy group, the PME / PDE ratios had decreased on follow -up MR spectroscopy. Despite, in the virological nonresponder group, the PME / PDE ratios on follow-up imaging were similar to the baseline values. CONCLUSION: 31P MRS can be used to provide biochemical information on hepatic metaboli c processes.This study indicates that the PME / PDE ratio can be used as an indicator of response to antiviral treatment in chronic hepatitis C patients.