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目的在缺血性脑卒中患者中探讨高同型半胱氨酸血症(HHe)的危险因素。方法回顾性分析,将缺血性脑卒中患者690例,分为伴HHe组329例,不伴HHe组361例,调查年龄、性别、症状、体征、吸烟饮酒史,是否伴高血压病、糖尿病病史,血浆同型半胱氨酸(Hcy)、叶酸、维生素B12、胆固醇(TC)、甘油三酯(TG)浓度。用logistic回归进行统计学分析。结果性别、年龄、吸烟指数、叶酸、维生素B12浓度进入logistic回归模型,[OR=2.279(95%CI1.498～3.524),OR=1.039(95%CI1.022～1.056),OR=1.001(95%CI1.000～1.001),OR=0.830(95%CI0.786～0.876),OR=0.998(95%CI0.997～0.999)]。结论男性、老龄、吸烟及叶酸和维生素B12浓度的降低为缺血性卒中患者HHe的独立危险因素。
Objective To investigate the risk factors of hyperhomocysteinemia (HHe) in patients with ischemic stroke. Methods Retrospective analysis of 690 patients with ischemic stroke was divided into 329 cases with HHe group, 361 cases without HHe group, to investigate the age, gender, symptoms, signs, history of smoking and drinking, whether with hypertension, diabetes History, plasma homocysteine (Hcy), folic acid, vitamin B12, cholesterol (TC) and triglyceride (TG). Logistic regression was used for statistical analysis. Results The sex, age, smoking index, folic acid and vitamin B12 concentration entered the logistic regression model, OR = 2.279 (95% CI 1.498-3.524), OR = 1.039 % CI 1.000 to 1.001), OR = 0.830 (95% CI 0.786-0.876), OR = 0.998 (95% CI 0.997-0.9999)]. Conclusions Male, old age, smoking and the reduction of folic acid and vitamin B12 concentrations are independent risk factors for HHe in patients with ischemic stroke.