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目的 了解重症肌无力患者自身抗体的产生与细胞因子的关系。方法 采用免疫酶点方法检测 2 2例重症肌无力患者外周血AChRAb分泌细胞和IFN γ分泌细胞。结果 重症肌无力患者外周血AChRAb分泌细胞和IFN γ分泌细胞均高于正常对照组 ,AChRAb和IFN γ之间呈高度正相关性 ,不同亚型之间两种分泌细胞差异均无显著性。结论 重症肌无力患者体内有IFN γ分泌细胞增高 ,IFN γ与AChRAb的相关性提示IFN γ可能对重症肌无力患者自身抗体的产生有促进作用。
Objective To understand the relationship between autoantibodies and cytokines in patients with myasthenia gravis. Methods Peripheral blood AChRAb secreting cells and IFN γ secreting cells were detected by enzyme-linked immunosorbent assay (ELISA) in 22 patients with myasthenia gravis. Results The levels of AChRAb secreting cells and IFNγ secreting cells in peripheral blood of patients with myasthenia gravis were significantly higher than those of the normal control group. There was a positive correlation between AChRAb and IFNγ. There was no significant difference between the two subtypes of secretory cells. Conclusions IFN γ secreting cells are increased in patients with myasthenia gravis. The correlation between IFN γ and AChRAb suggests that IFN γ may promote the production of autoantibodies in patients with myasthenia gravis.