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自发性高血压大鼠（ＳＨＲ）分为５组作实验。对照组ｌｍｇ／ｋｇ、哌唑嗪组０．３ｍｇ／ｋｇ、ｌｍｇ／ｋｇ、５ｍｇ／ｋｇ多沙唑嗪组。灌胃给药后３个剂量多沙唑嗪对ＳＨＲ２４ｈ的血压观察显示该药降压作用迅速且持久，血压于４ｈ达最低，于８ｈ仍显著降低，与呢唑嗪降血压作用类似。连续３周降血压治疗实验，多沙唑嗪同样有明显的降血压作用，也与哌唑嗪一致。ｌｍｇ／ｋｇ多次唑嗪静脉注射使麻醉ＳＨＲ血压迅速而持久下降，对心电图、心率和呼吸率无明显影响。
Spontaneous hypertensive rats (SHR) were divided into five groups for experiments. The control group lmg / kg, prazosin group 0.3mg / kg, lmg / kg, 5mg / kg doxazosin group. 3 doses of doxazosin after intragastric administration of SHR24h blood pressure showed that the antihypertensive effect of the drug quickly and long-lasting, blood pressure at 4h reached the lowest, still significantly reduced at 8h, and the effect of antihypertensive effect of doxazosin. 3 consecutive weeks of antihypertensive treatment experiments, doxazosin also have obvious antihypertensive effect, but also with prazosin consistent. Intravenous injection of lmg / kg doxazosin anesthetized SHR rapid and sustained decline in blood pressure, ECG, heart rate and respiratory rate had no significant effect.