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用离体实验法研究ι─荷包牡丹碱对豚鼠结肠带收缩的影响，结果发现：ι─荷包牡丹碱明显拮抗组织胺及ｃａ２＋引起的收缩，呈现非竞争性拮抗方式，ｐＤ＇２分别为４．９２及５．４３．在无ｃａ２＋液中，ι─荷包牡丹碱与罂粟碱相似，能抑制组织胺诱发的结肠带收缩．提示两药对结肠带依赖细胞内Ｃａ２＋所致的收缩均有明显的抑制，当恢复细胞外Ｃａ２＋浓度后，两药对依赖细胞外Ｃａ２＋经ＲＯＣ内流所致的收缩无影响．
The effect of ι-bicuculline on contractile activity of guinea pig colon strips was investigated by in vitro experiments. The results showed that ι-bicuculline significantly antagonized the contraction induced by histamine and ca2 +, showing a noncompetitive antagonistic manner with pD’2 values of 4 .92 and 5.43. In ca2 + -free solution, ibuprofen is similar to papaverine and inhibits histamine-induced contractions of the colon. These results suggest that both drugs inhibit the contractility induced by intracellular Ca2 + in colonic strips obviously. When the extracellular Ca2 + concentration is restored, the two drugs have no effect on the contraction of extracellular Ca2 + dependent on influx of ROC.