本文综述了烟碱受体变构调节的证据和变构调节剂的种类 ,指出变构调节发生在烟碱受体除识别位点以外的多个位点上 ,这些位点在受体与细胞膜交界的外侧、内侧、离子通道中和细胞膜上。膜片钳技术是重要研究手段之一 ,根据变构调节剂导致的烟碱受体性质的改变能确定它们的作用位点 ,这为进一步阐明烟碱受体的性质和明确一些药物的作用机制提供了依据 This review summarizes the evidence for the allosteric modulation of nicotinic receptors and the types of allosteric modulators, pointing out that allosteric modulation occurs at nicotinic receptors at sites other than the recognition site, Junction outside, inside, ion channels and on the cell membrane. Patch-clamp technique is one of the most important research methods. Based on the changes of nicotinic receptors caused by allosteric modulators, their location can be determined. This is the first step to further elucidate the properties of nicotinic receptors and elucidate the mechanism of action of some drugs Provided the basis