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以武汉市某小学儿童1160名为对象,共查出贫血儿童269人.从中筛选70名,随机分为两组,一组补铁,一组服安慰剂,另设正常对照,连续3个月观察实验前后Hb、FEP、SF及IQ变化情况.结果发现:补铁组各血液指标均恢复正常;智商测定,补铁组3个月前后比较,P<0.05.单因素分析,发现儿童年龄与母亲孕龄对智商有明显影响;多因素分析提示儿童年龄等8个因素对智商作用显著.以上表明:铁缺乏对儿童智力有明显影响,经铁剂治疗能在短期内恢复正常.
A total of 1160 children from a primary school in Wuhan were enrolled and 269 children with anemia were detected.Seventy patients were screened and randomly divided into two groups with one group of iron supplements and one group of placebo and another group of normal controls for 3 months The changes of Hb, FEP, SF and IQ before and after the experiment were observed.The results showed that all the blood parameters in the iron-supplemented group returned to normal.The IQ of the iron supplementation group was significantly higher than that of the iron supplementation group after 3 months, P <0.05.Univariate analysis showed that children’s age and Maternal gestational age had a significant effect on IQ; Multivariate analysis suggested that 8 factors such as children’s age had a significant effect on IQ, which indicated that iron deficiency had a significant effect on children’s intelligence, and iron treatment could return to normal within a short period of time.