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棉酚作为一种男用节育药被发现以来,人们对其作用原理、药物毒性、药物动力学及其遗传效应进行了大量的研究。结果表明,服用抗生育剂量的棉酚或在较小量棉酚存在的条件下进行细胞培养都没有引起染色体畸变率的增加。为了弄清长期服用抗生育剂量棉酚个体的姐妹染色单体交换(SCE)率有无变化,我们对14名服药30个月以上的个体(平均服药时间为38.4月)和11名同年龄组对照个体的外周血淋巴细胞的SCE率进行了比较分析。取服用醋酸棉酚个体和对照个体的静
Since gossypol was discovered as a male sterility medicine, a great deal of research has been conducted on its action principle, drug toxicity, pharmacokinetics and its genetic effect. The results showed that the use of anti-fertility dose of gossypol or cell culture in the presence of a small amount of gossypol did not cause an increase in chromosome aberration rates. To determine whether there was any change in sisters chromatid exchange (SCE) rate among long-term doses of ginsenoside-resistant individuals, we evaluated 14 subjects who took drugs for more than 30 months (mean duration of medication was 38.4 months) and 11 same age groups SCE rates of peripheral blood lymphocytes in control individuals were compared. Take taking gossypol acetate individuals and control individuals