大肠癌是世界范围内最常见的癌症之一,在西方社会其发病率排在肿瘤的第2位,在我国的消化道肿瘤中排第4位。尽管手术、放疗、化疗技术不断提高,但5年生存率低于50%。随着科学技术的发展,125I粒子永久性组织间植入内放射已成为大肠癌治疗的新方法,本文综述了125I粒子永久性组织间植入内放射治疗大肠癌的研究进展。 Colorectal cancer is one of the most common cancers in the world. Its incidence is the second in the western society and fourth in the gastrointestinal cancer in China. Although surgery, radiotherapy, chemotherapy and continuous improvement, but 5-year survival rate of less than 50%. With the development of science and technology, permanent implantation of radioactive 125I particles has become a new method for the treatment of colorectal cancer. This review summarizes the research progress of permanent 125I seeds implantation for radiotherapy of colorectal cancer.